Metabolism switch signals end for healing hearts

Researchers have identified the process that shuts down the human heart's ability to heal itself, and are now searching for a drug to reverse it.

University of Queensland's Dr James Hudson and Murdoch Children's Research Institute researcher Dr Enzo Porrello have shown a metabolic pathway governs the loss of the heart's proliferative capacity.

"A switch in a newborn's metabolism means this ability to regenerate heart tissue disappears, usually within a week," Dr Hudson said.

"Now we have identified the process that causes this to occur, we believe there could be an opportunity to reactivate regeneration in adult hearts."

The research also involved collaborators from AstraZeneca in Sweden, the University of Sydney and the University of Melbourne.

Dr Hudson's team is now working with a company to identify drugs that could re-activate the heart's ability to self-repair.

"That would mean a heart could repair muscle damage caused from a heart attack, and recover its full capacity to pump blood around the body," Dr Hudson said.

The research was performed in engineered human heart tissues grown from stem cells in the Cardiac Regeneration Laboratory at UQ's School of Biomedical Sciences.

Credit: University of Queensland

It follows a study which mapped cell pathways in mouse hearts.

"We undertook profiling to separate the different cell populations and pathways, in hearts with regeneration capacity and those without," Dr Hudson said.

"This highlighted the metabolic pathway we focused on in our latest research."

About 54,000 Australians suffer a heart attack each year, with an average of about 23 deaths every day.

The research was published in PNAS and Circulation.

Explore further: Scientists create 'beating' human heart muscle for cardiac research

More information: Gregory A. Quaife-Ryan et al. Multicellular Transcriptional Analysis of Mammalian Heart Regeneration, Circulation (2017). DOI: 10.1161/CIRCULATIONAHA.117.028252

Richard J. Mills et al. Functional screening in human cardiac organoids reveals a metabolic mechanism for cardiomyocyte cell cycle arrest, Proceedings of the National Academy of Sciences (2017). DOI: 10.1073/pnas.1707316114

Journal reference: Proceedings of the National Academy of Sciences Circulation

Provided by: University of Queensland

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